A Novel Vehicle Formulation for Treatment of Inflammatory Skin Diseases
A. Zemtsov, H. Hosier
Objective: To test the efficacy of a new topical vehicle formulation containing cetirizine in emu oil in treating inflam-matory skin conditions.
Methods: A single blind half body comparative study of patients with psoriasis, atopic and stasis dermatitis were all treated with midpotency topical steroid (desoximethasone) in propylene glycol base, desoxi-methasone and cetirizine in propylene glycol base, desoximethasone in emu oil base and desoximethasone with cetiriz-ine dissolved in emu oil.
Results: Based on patients’ ranking of creams’ efficacy, and supported by photographic data and investigators’ clinical assessment, results clearly indicated that desoximethasone and cetirizine in emu base was statistically more efficacious than either desoximethasone alone or with cetirizine in neutral propylene glycol base or desoximethasone in emu oil base (without cetirizine). Conclusions: Cetirizine and emu oil, having inherent anti-in-flammatory and other beneficial properties synergistically, and by different biochemical pathways, enhance and mag-nify each other’s pharmaceutical effects that are useful in treatment of skin inflammatory diseases.
Journal of Cosmetics, Dermatological Sciences and Applications, 2013, 3, 18-21